Abstract
Green barley leaf extract, a dried extract of young green barley leaves, is widely used in Japan and other countries as a nutritional supplement. We have recently reported (Badamchian, et.al J. Nutr. Bioc. 5:145-150, 1994), the isolation of a vitamin E analog from green barley leaf extract that stimulates release of prolactin and growth hormone from rat anterior pituitary cells in vitro. This molecule was identified as α-Tocopherol succinate, an analog of α-Tocopherol, or vitamin E. In the present study we tested the commercially available forms of α-Tocopherol and also succinic acid. Treatment of normal anterior pituitary cells with different forms of tocopherol (100μg/ml) and succinic acid (50-100μg/ml) caused significant increase (p<0.01) in prolactin and growth hormone release in only α-Tocopherol succinate-treated cells. α-Tocopherol, δ-Tocopherol, α-Tocopherol acetate, α-Tocopherol nicotinate, succinic acid disodium salt, and succinic acid butenedoic acid did not effect the prolactin and growth hormone release in vitro. Supported by a gift from Hagiwara Institute of Health, Hyogo, Japan.
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Badamchian, M., Spangelo, B., Hagiwara, Y. et al. Alpha-Tocopherol Succinate, But Not Alpha-Tocopherol Or Other Vitamin E Analogs Stimulates Prolactin And Growth Hormone Release From Rat Anterior Pituitary Cells in vitro. Neuropsychopharmacol 11, 265 (1994). https://doi.org/10.1038/sj.npp.1380135
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DOI: https://doi.org/10.1038/sj.npp.1380135