Cells are the building blocks of life. Ideas traditionally applied to physical problems are now helping to unravel their complex mysteries.
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References
Timofeeff-Ressovsky, N. W., Zimmer, K. G. & Delbrück, M. Nachr. Ges. Wiss. Gött. 1, 189–245 (1935).
Schrödinger, E. What is Life? (Cambridge Univ. Press, 1944).
Bustamante, C., Liphardt, J. & Ritort, F. Phys. Today 58, 43–48 (2005).
Jarzynski, C. Phys. Rev. Lett. 78, 2690–2693 (1997).
Liphardt, J., Dumont, S., Smith, S. B., Tinoco, I. Jr & Bustamante, C. Science 296, 1832–1835 (2002).
Collin, D. et al. Nature 437, 231–234 (2005).
Crooks, G. E. Phys. Rev. E 60, 2721–2726 (1999).
Prost, J., Joanny, J-F. & Parrondo, J. M. R. Phys. Rev. Lett. 103, 090601 (2009).
Seifert, U. Phys. Rev. Lett. 104, 138101 (2010).
Hayashi, K., Ueno, H., Iino, R. & Noji, H. Phys. Rev. Lett. 104, 218103 (2010).
Pelham, R. J. & Wang, Y-L. Proc. Natl Acad. Sci. USA 94, 13661–13665 (1997).
Balaban, N. Q. et al. Nature Cell Biol. 3, 466–472 (2001).
Engler, A., Sen, S., Sweeney, H. L. & Discher, D. E. Cell 126, 677–689 (2006).
Zemel, A. et al. Nature Phys. 6, 468–473 (2010).
Basan, M. et al. HFSP J. 3, 265–272 (2009).
Liu, A. P. & Fletcher, D. Nature Rev. Mol. Cell Biol. 10, 644–650 (2009).
Gittes, F. et al. Phys. Rev. Lett. 79, 3286–3289 (1997).
MacKintosh, F. C. & Schmidt, C. F. Curr. Opin. Cell Biol. 22, 29–35 (2010).
MacKintosh, F. C. & Levin, A. J. Phys. Rev. Lett. 100, 018104 (2008).
Humphrey, D. et al. Nature 416, 413–416 (2002).
Reister, E. et al. Phys. Rev. Lett. 101, 208103 (2008).
Smith, A-S. & Sackmann, E. ChemPhysChem 10, 66–78 (2009).
Weik, T. R. & Lipowsky, R. Phys. Rev. E 64, 011903 (2001).
Smith, A-S. et al. Proc. Natl Acad. Sci. USA 105, 6906–6911 (2008).
Smith, A-S., Fenz, S. F. & Sengupta, K. Europhys. Lett. 89, 28003 (2010).
Limozin, L. & Sackmann, E. Phys. Rev. Lett. 89, 168103 (2002).
Pontani, L-L. et al. Biophys. J. 96, 192–198 (2009).
Acknowledgements
This Perspective aims to briefly introduce some of the research topics in cell biophysics rather than present a comprehensive overview of the literature. I acknowledge that the mention of the work of many others would be equally appropriate. I thank all my colleagues and students for having the patience to discuss with me the topics that inspired this manuscript. My particular gratitude goes to E. Sackmann, U. Seifert, K. Sengupta and F. Rehfeldt.
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Smith, AS. Physics challenged by cells. Nature Phys 6, 726–729 (2010). https://doi.org/10.1038/nphys1798
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DOI: https://doi.org/10.1038/nphys1798
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