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Protein therapies face challenges including short half-lives, high cost, and dangerous side effects at concentrations required for efficacy. S. Stupp, S. Lee, T. Fyrner, W. Hsu, E. Hsu, and co-workers have now developed glycopeptide nanostructures that potentiate protein signalling to cells by mimicking the biological function of sulfated glycans. The concept was demonstrated using a model of spinal fusion in which bone regenerated with a growth factor dose that was 100-fold lower than required in the animal model. The cover image depicts a human spine covered with an artist's impression of the nanostructure surfaces that display hundreds of thousands of sulfated sugar molecules to activate proteins.
Risk assessment and life-cycle assessment provide complementary information on the impact of a technology on the environment. We present diverging opinions on how to integrate the two approaches to best evaluate the environmental impact of engineered nanomaterials.
The time has come to implement a regulatory framework tailored to manufactured materials. I propose a new legislative framework that combines registration, evaluation, authorization and categorization of nanomaterials.
The absence of nanotechnology-specific insurance policies could be detrimental to the development of the nanotechnology industry. Better communication between insurers and scientists is an essential step to provide a regulatory framework protecting both producers and consumers.
Risk assessment and life cycle assessment are both needed in the environmental evaluation of engineered nanomaterials. Scientists from both fields should collaborate intensively to deal with mutual challenges to achieve a complete and comprehensive assessment.
The advantages and challenges of integrating the methods of life-cycle assessment and risk assessment are discussed in terms of the objectives for evaluating nanotechnologies in a safe and sustainable way.
Nanoscale plasma membrane curvature, generated in a controllable fashion by vertically aligned nanostructure arrays, promotes the accumulation of key endocytic proteins in live cells.
A multivalent bi-specific nanoconjugate can promote immune cells to recognize and eradicate cancer cells in a receptor targeted manner, leading to the generation of potent and durable anti-tumour immunity.
Soft phononic clamping dilutes the intrinsic dissipation of a mechanical resonator's material by five orders of magnitude, enabling a record value of the product between frequency and quality factor at room temperature, and mechanical coherence times otherwise only available in optical or Paul traps.
The implementation of bio-inspired sparse coding algorithms aimed at image processing is demonstrated by exploiting 32 × 32 crossbar arrays of analogue memristors.
A self-assembled monolayer with terminal ferrocene groups involves a different number of molecules in the transport of charges depending on the polarity of the voltage bias.
Highly bioactive supramolecular nanostructures displaying sulfated glycopeptides on their surfaces were designed in order to mimic the polysaccharides that bind and activate a plethora of proteins in mammalian biology during development and tissue regeneration.