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Volume 12 Issue 8, August 2017

Protein therapies face challenges including short half-lives, high cost, and dangerous side effects at concentrations required for efficacy. S. Stupp, S. Lee, T. Fyrner, W. Hsu, E. Hsu, and co-workers have now developed glycopeptide nanostructures that potentiate protein signalling to cells by mimicking the biological function of sulfated glycans. The concept was demonstrated using a model of spinal fusion in which bone regenerated with a growth factor dose that was 100-fold lower than required in the animal model. The cover image depicts a human spine covered with an artist's impression of the nanostructure surfaces that display hundreds of thousands of sulfated sugar molecules to activate proteins.

Article p821

IMAGE: MARK SENIW, SIMPSON QUERREY INSTITUTE, NORTHWESTERN UNIVERSITY

COVER DESIGN: DAVID SHAND

Editorial

  • Risk assessment and life-cycle assessment provide complementary information on the impact of a technology on the environment. We present diverging opinions on how to integrate the two approaches to best evaluate the environmental impact of engineered nanomaterials.

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Commentary

  • The time has come to implement a regulatory framework tailored to manufactured materials. I propose a new legislative framework that combines registration, evaluation, authorization and categorization of nanomaterials.

    • Steffen Foss Hansen
    Commentary
  • The absence of nanotechnology-specific insurance policies could be detrimental to the development of the nanotechnology industry. Better communication between insurers and scientists is an essential step to provide a regulatory framework protecting both producers and consumers.

    • Finbarr Murphy
    • Martin Mullins
    • Trevor Maynard
    Commentary
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Research Highlights

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News & Views

  • The adjustable resistive state of memristors makes it possible to implement sparse coding algorithms naturally and efficiently.

    • Bruno A. Olshausen
    • Christopher J. Rozell
    News & Views
  • Resonant photonic structures made of thermoelectric materials can convert light into electricity without wavelength limitations.

    • Ming Zhou
    • Zongfu Yu
    News & Views
  • A diode made of a self-assembly monolayer with ferrocenyl termini shows an on/off ratio of 105.

    • Nicolas Clement
    • Akira Fujiwara
    News & Views
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Perspective

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Letter

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Article

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Corrigendum

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In the Classroom

  • Themis Prodromakis explains how to engage primary school students in nanotechnology — even outside the classroom.

    • Themis Prodromakis
    In the Classroom
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