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In this Perspective, the authors discuss the importance and current challenges of using genomic data to predict the emergence of infectious disease outbreaks, and propose the next steps to integrate genomics and modelling for infectious diseases forecasting.
Combined host transcriptional profiling and metagenomic pathogen detection of whole blood and plasma samples from critically ill patients enables the generation of classifiers for reliable prediction of sepsis.
Characterization of bacterial auxin degradation loci and their regulators reveals two distinct types across plant microbiome species, where only one, exemplified in Variovorax species, can interfere with root growth inhibition in a complex synthetic microbial community.
A CRISPR-based oligo recombineering (CORe) approach functionally prioritizes electrophile-sensitive cysteines in Toxoplasma gondii and promotes anti-parasitic drug discovery.
Detection of monkeypox viruses (MPXV) in archival testes samples from acute and convalescent MPXV-infected macaques provides evidence supporting the potential for sexual transmision of MPXV.
The authors review archaeal morphology, surface features, internal organization and cell division, discussing the state of the art and future research directions.
Longitudinal population deep sequencing of Streptococcus pneumoniae sampled from infants and their mothers improves our understanding of the dynamics of colonization, transmission, inter-strain competition and the impact of antibiotic treatment.
Comprenhensive analysis of human antibody responses to SARS-CoV-2 variants and animal sarbecoviruses finds that Omicron escapes neutralization more readily than distantly related animal sarbecoviruses.
The SIR2-domain-containing protein DSR2 from Bacillussubtilis protects against SPR phage infection via NAD+ depletion. Some phages express anti-DSR2 proteins, blocking bacterial immunity.
Short pAgo proteins associate with the Sir2 effector from Geobacter sulfurreducens to induce abortive infection via NAD+ depletion and provide defence against invading DNA.
Efforts to futureproof global microbial biodiversity are proposed, in particular in managed landscapes, to monitor, manage and restore the soil fungal microbiome.
Type IV CRISPR systems that interfere with the transmission of mobile genetic elements are poorly understood. Here the authors show that a Pseudomonas Type IV-A system targets DNA in a PAM-dependent manner without DNA nuclease activity.
Probiotics given to preterm infants not only persist but restructure early-life microbiota, which presents an opportunity to optimize developmental outcomes and a responsibility to fully understand the long-term consequences.
We present a series of commissioned articles authored by people from groups that are under-represented in research, to highlight past and present scientific contributions in microbiology and to increase the diversity of Nature Microbiology authors.
A computational analysis of biosynthetic gene clusters with unique structural features unveils new natural product scaffolds, leading to the discovery of an antibiotic targeting BamA with activity against Gram-negative pathogens.