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Stable isotope-labelled amino acid incorporation into proteins reveals that genetically homogeneous yeast colonies contain metabolically distinct subpopulations that cross-feed each other and are phenotypically diverse.
Deployment of some CRISPR-Cas systems stunts host growth by degrading all transcripts, but Listeria seeligeri reverses dormancy using restriction-modification-based phage DNA targeting.
Systems genetics reveals interactions between host and microbial phenotypes in the murine gut, including a role for Akkermansia muciniphila in the production of immunomodulatory ornithine lipids.
Single-cell imaging, metabolomics and modelling quantify metabolic exchanges between cyanobacteria and heterotrophic bacteria, showing transient nutritional exchanges facilitated by chemotaxis of the heterotroph.
Application of reprogrammed bacteriophage to functional metagenomics in clinically relevant bacterial strains improves identification of antibiotic resistance genes, including those against recently developed or approved antibiotics.
Resource allocation in bacteria and adaptation to nutritional downshifts are characterized using a combination of quantitative proteomics and coarse-grained physiological modelling.
Human cytomegalovirus (HCMV) has two modes of infection: productive and latent. Tracking HCMV infection with single-cell transcriptomics revealed that infection outcome (productive or latent) is based on viral gene expression levels at early stages of infection. Moreover, intrinsic levels of interferon-stimulated genes affect viral gene expression and the outcome of infection.
Temporal single-cell RNA sequencing analysis of viral and host transcriptional responses during human cytomegalovirus infection of macrophages and monocytes reveals molecular features influencing distinct infection courses and suggests additional latency reservoirs.
Rebound virus in the cerebrospinal fluid revealed viral lineages selected for growth in T cells that were clonally amplified and often distinct from the majority of rebound viral lineages in the blood.
Phage-encoded endolysins released from lysed bacteria trigger neighbouring cells to convert into cell wall-deficient L-forms that are resistant to subsequent phage infection.
Isolation and characterization of a selfish genetic element with a virophage lifestyle that co-infects a bloom-forming polar algae along with a partner virus.
Cytotoxic CD8+ T cells reduce the average lifespan of productively infected cells during acute simian immunodeficiency virus infection (a primate model of human immunodeficiency virus infection). However, they are ineffective at preventing the establishment of a persistent reservoir of latently infected cells under long-term antiretroviral therapy.