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The metavirome of 31 tick species sheds light on the diversity and distinct evolution of tick-associated RNA viruses, and lays the foundation for better understanding of tick–virus interaction.
Metabolic variation via a single substitution in the β-carbonic anhydrase CanB determines CO2 dependence and influences fluoroquinolone resistance in Neisseria gonorrhoeae.
The CRISPR–Cas9 system is widely studied for its role as a phage defence system and for gene editing applications, but its evolutionary origins are poorly understood. Here the authors use ancestral sequence reconstruction to determine the evolutionary history and ancient protein sequences of Streptococcus pyogenes Cas9 ancestors.
Head-to-head comparison of third doses of mRNA COVID-19 vaccines in US Veterans finds that both are effective against documented SARS-CoV-2 infection and severe COVID-19 outcomes.
The SARS-CoV-2 Africa dashboard is an interactive tool that enables visualization of SARS-CoV-2 genomic information in African countries. The customizable app allows users to visualize the number of sequences deposited in each country, and the variants circulating over time. Our dashboard enables near real-time exploration of public data that can inform policymakers, healthcare professionals and the public about the ongoing pandemic.
Longitudinal sampling of patients with hepatitis C virus before and after elimination of the virus reveals links between functions of the gut microbiome and liver disease.
Multi-omics analyses of gut microbiome, liver and blood samples from patients with hepatitis C infection before and after removal of the virus reveal metabolic dysregulation along the gut–liver axis.
Reports of diphtheria cases in asylum seekers in the UK remind us that understanding and mitigating the risks posed by infectious diseases to disadvantaged peoples remain important.
This Resource combines amplicon sequencing, shotgun metagenomic sequencing and untargeted metabolomics to provide a global view of microbial–metabolite associations across Earth’s environments.
Genomic analyses of Klebsiella isolates sampled from multiple human, animal and environmental sources in Northern Italy explore Klebsiella population diversity and show that transmission of multidrug-resistant clones between clinical and environmental settings is scarce.