Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Faecal viromes of 647 healthy infants were deeply sequenced to identify more than 230 previously undescribed gut virus families, expanding known diversity within the human infant gut virome.
Breakthroughs in developing an effective human immunodeficiency virus (HIV) vaccine have been rare despite decades of effort. By combining vaccination with a topical microbicide that also potentiates vaccine-induced immunity, 16 out of 20 female macaques were protected against vaginal acquisition of the highly pathogenic simian immunodeficiency virus (SIV).
Metagenomics and Hi-C proximity-ligation sequencing show that viruses in dense microbial communities can interact with multiple, distantly related microbial hosts.
Characterization of an ancient chemosynthetic process in modern oceans prompts investigation into microbial metabolisms that might be hiding in the dark.
Fc–Fc gamma receptor interactions and alveolar macrophages contribute to ancestral vaccine-induced control of infection with SARS-CoV-2 variants in mice.
Comparison of mucosal and systemic immunity after vaccination with the live-attenuated vaccine sCPD9, mRNA vaccine BNT162b2 or an adenovirus-vectored vaccine following SARS-CoV-2 challenge in hamsters.
ProBac-seq is a method that uses libraries of DNA probes and commercial microfluidics for single-cell RNA-seq, leveraged here to show heterogeneous gene expression in clonal bacterial cultures including variable toxin expression in an agricultural strain of Clostridium.
Previous studies have suggested the presence of a ‘blood microbiome’. Here, we analysed sequencing data generated from the blood of 9,770 healthy individuals and found no evidence for a common blood microbiome in these individuals.
Detection of persistent replication-competent HIV in monocytes from virologically suppressed people with HIV indicates that monocytes have a role as a latent reservoir.
Colonoids derived from adult human stem cells support growth of human enterovirus. Instead of spreading through the epithelium or lysing infected cells, virus is released within intact infected cells. Infected cells are detected by force-sensing ion channels, a mechanism akin to that used for normal turnover of uninfected epithelia.
Bile salt hydrolases encoded by the gut microbiome shape the bile acid pool, including microbial conjugated bile acids, which impact Clostridioides difficile infection in the murine gut.