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Teresa O’Meara recounts her experience of approaching the emerging fungal pathogen, Candida auris, with an open mind, enabling her laboratory to uncover its unique biology.
Our study investigated microbial dynamics involved in the relative enrichment of oral bacteria in faeces. Results in mice and from human patients indicated that high percentages of oral bacteria reflect a depleted gut microbiota, with oral bacteria simply passing through rather than expanding in the gut, which has implications for gastrointestinal disease treatment.
Interactions between Peptostreptococcus anaerobius and host cells promote recruitment and activation of myeloid-derived suppressor cells, leading to anti-PD1 immune checkpoint inhibitor resistance and exacerbated colorectal cancer in mice.
Propionate supplementation alleviates methylmalonyl-CoA deficiency in Mycobacterium tuberculosis to maintain PDIM virulence lipid production and select against the emergence of less virulent PDIM-negative mutants that affect experimental reliability and BCG vaccine efficacy.
This Perspective discusses the basic biology, evolution and transmission of poxviruses, in particular monkeypox virus, and how this can help predict and manage potential future outbreaks.
Studying the host response to infection advances our biological and evolutionary understanding, while broadening our capacity to prevent and mitigate infectious diseases.
Increased relative abundance of oral bacteria in faecal samples can be explained by the marker hypothesis—their relative increase reflects the depletion of other microbiota members—which has implications for patient outcomes and microbiota-directed therapies.
Exoglycosidases isolated from the mucolytic gut bacteria Akkermansia muciniphila bring enzymatic conversion of A and B blood group erythrocytes to blood group O a step closer.