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Sophie E. Darch & Rebecca Gabrilska

Current Issue

Read the August issue of Nature Microbiology now 

Latest Research

  • Article |

    A new class of drugs, hexahydroquinolines, inhibits host haemoglobin endocytosis by Plasmodium falciparum and displays both therapeutic and transmission-blocking activities.

    • Manu Vanaerschot
    • , Leonardo Lucantoni
    • , Tao Li
    • , Jill M. Combrinck
    • , Andrea Ruecker
    • , T. R. Santha Kumar
    • , Kelly Rubiano
    • , Pedro E. Ferreira
    • , Giulia Siciliano
    • , Sonia Gulati
    • , Philipp P. Henrich
    • , Caroline L. Ng
    • , James M. Murithi
    • , Victoria C. Corey
    • , Sandra Duffy
    • , Ori J. Lieberman
    • , M. Isabel Veiga
    • , Robert E. Sinden
    • , Pietro Alano
    • , Michael J. Delves
    • , Kim Lee Sim
    • , Elizabeth A. Winzeler
    • , Timothy J. Egan
    • , Stephen L. Hoffman
    • , Vicky M. Avery
    •  & David A. Fidock
  • Letter |

    Metagenomic analyses reveal that microbial genomes undergo a community-wide transition in size and GC content across a narrow depth range, indicating that nutrient limitation is a major driver in marine microbial genomic and proteomic evolution.

    • Daniel R. Mende
    • , Jessica A. Bryant
    • , Frank O. Aylward
    • , John M. Eppley
    • , Torben Nielsen
    • , David M. Karl
    •  & Edward F. DeLong
  • Article |

    During acute HIV type 1 infection, a subset of γδ T cells that express Δ42PD1 are shown to home to the gut, where they activate innate immunity and inflammation through direct interaction of Δ42PD1 with Toll-like receptor 4. Blockade of this pathway reduces mucosal damage.

    • Allen Ka Loon Cheung
    • , Hau-yee Kwok
    • , Yiru Huang
    • , Min Chen
    • , Yufei Mo
    • , Xilin Wu
    • , Ka-shing Lam
    • , Hoi-Kuan Kong
    • , Terrence Chi Kong Lau
    • , Jingying Zhou
    • , Jingjing Li
    • , Lin Cheng
    • , Boon Kiat Lee
    • , Qiaoli Peng
    • , Xiaofan Lu
    • , Minghui An
    • , Hui Wang
    • , Hong Shang
    • , Boping Zhou
    • , Hao Wu
    • , Aimin Xu
    • , Kwok-Yung Yuen
    •  & Zhiwei Chen
  • Letter |

    Isolation of a cyanophage encoding photosystem I genes reveals that these are expressed during infection and inserted into host membranes, resulting in enhanced electron flow, and that phage carrying these genes are abundant in marine environments.

    • Svetlana Fridman
    • , José Flores-Uribe
    • , Shirley Larom
    • , Onit Alalouf
    • , Oded Liran
    • , Iftach Yacoby
    • , Faris Salama
    • , Benjamin Bailleul
    • , Fabrice Rappaport
    • , Tamar Ziv
    • , Itai Sharon
    • , Francisco M. Cornejo-Castillo
    • , Alon Philosof
    • , Christopher L. Dupont
    • , Pablo Sánchez
    • , Silvia G. Acinas
    • , Forest L. Rohwer
    • , Debbie Lindell
    •  & Oded Béjà
  • Article |

    A genome-wide association approach identifies differential biofilm and virulence attributes associated with mortality in two Staphylococcus aureus clonal complexes.

    • Mario Recker
    • , Maisem Laabei
    • , Michelle S. Toleman
    • , Sandra Reuter
    • , Rebecca B. Saunderson
    • , Beth Blane
    • , M. Estee Török
    • , Khadija Ouadi
    • , Emily Stevens
    • , Maho Yokoyama
    • , Joseph Steventon
    • , Luke Thompson
    • , Gregory Milne
    • , Sion Bayliss
    • , Leann Bacon
    • , Sharon J. Peacock
    •  & Ruth C. Massey
  • Article |

    The group A streptococcal M protein virulence factor induces inflammasome activation during infection.

    • J. Andrés Valderrama
    • , Angelica M. Riestra
    • , Nina J. Gao
    • , Christopher N. LaRock
    • , Naveen Gupta
    • , Syed Raza Ali
    • , Hal M. Hoffman
    • , Partho Ghosh
    •  & Victor Nizet

News & Comment

  • Editorial |

    Fungal pathogens are virtually ignored by the press, the public and funding bodies, despite posing a significant threat to public health, food biosecurity and biodiversity.

  • News and Views |

    The discovery and genomic characterization of a new group of extreme halophilic methanogens sheds light on the origin of methanogenesis and the evolution of the Haloarchaea.

    • Anja Spang
    •  & Thijs J. G. Ettema
  • News and Views |

    Co-culture of bacterial cells engineered with quorum-sensing and self-lysis circuits allows coupled oscillatory dynamics and stable states, opening the way to engineered microbial ecosystems with targeted dynamics and extending gene circuits to the ecosystem level.

    • Alfonso Jaramillo
  • Editorial |

    The WHO's plans to bolster global vector control measures blend audacious goals with a sensible approach that could save lives and stimulate economic growth and development in many of the world's poorest nations.

  • News and Views |

    Nitric oxide synthase has long been associated with control of Mycobacterium tuberculosis infection. However, new work reveals that instead of directing an antibacterial killing response, nitric oxide is critical for restraining granulocytic inflammation, which can provide a nutrient-rich niche for increased bacterial growth.

    • Christina L. Stallings

Current Issue

Volume 2 Issue 8

Image: D. Y. Sorokin, Cover Design: Samantha Whitham

Volume 2 Issue 8

A pinch of salt

Methanonatronarchaeia are a distinct class-level lineage of extremely halophilic methanogens, which lack features of classical methanogenesis and have a high intracellular concentration of potassium, suggesting pottasium-based osmoprotection.

See Sorokin et al. 2, 17081 (2017)

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