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A simple 'smart-pooling' screening strategy for large-scale systems biology experiments promises to provide considerable improvement in experimental efficiency, while simultaneously allowing improved accuracy and coverage.
A recently developed multigene viral expression system is put to work to generate mice carrying a single T-cell receptor (TCR) specificity. Complementing the transgenic-mice technique, this method offers new practical options to researchers studying T-cell development.
Directly or indirectly, most cell biologists study cell signaling, a field whose complexity has grown geometrically with recent advances in molecular biology. Combining refinements of older techniques with innovative new methods can help researchers traverse this rapidly expanding field. Alan Dove reports.
