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Volume 3 Issue 10, October 2006

Winner of the 2006 Nikon Small World photomicrography competition. The competition is described by its sponsor as a "forum for showcasing the beauty and complexity of life as seen through the light microscope", and it rewards scientists worldwide who marry scientific accuracy with an artistic eye (http://www.nikonsmallworld.com/). This year's first-prize winning image by Paul L. Appleton from the Division of Cell and Developmental Biology, University of Dundee, UK, shows cell nuclei of the mouse colon (740x) using two-photon fluorescence.

Volume 3 Issue 10

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Editorial

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Correspondence

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Research Highlights

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Commentary

  • Large-scale RNA interference (RNAi)-based analyses, very much as other 'omic' approaches, have inherent rates of false positives and negatives. The variability in the standards of care applied to validate results from these studies, if left unchecked, could eventually begin to undermine the credibility of RNAi as a powerful functional approach. This Commentary is an invitation to an open discussion started among various users of RNAi to set forth accepted standards that would insure the quality and accuracy of information in the large datasets coming out of genome-scale screens. Please visit methagora to view and post comments on this article

    • Christophe J Echeverri
    • Philip A Beachy
    • René Bernards
    Commentary
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News & Views

  • Methods to simultaneously localize the positions of multiple single fluorophores by precisely determining their individual positions are now yielding impressive gains in fluorescence microscopy resolution.

    • W E Moerner
    News & Views

  • The combination of appropriate labeling and a new imaging software allows researchers to follow the progress of individual HIV particles within infected cells with outstanding precision.

    • David McDonald
    News & Views
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Perspective

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Brief Communication

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Article

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Protocol

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Technology Feature

  • More and more scientists now see advantages in automating some of their more repetitive or error-prone tasks. Michael Eisenstein takes a look at systems that are helping to bring robotics into the academic and clinical research laboratory.

    • Michael Eisenstein
    Technology Feature
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Erratum

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Advertising Feature: Application Note

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