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Volume 12 Issue 11, November 2015

Eye of a honeybee covered in dandelion pollen (120x magnification), photographed using reflected light illumination and constructed from about 150 separate stacked images by Ralph Claus Grimm, Jimboomba, Queensland, Australia. Winner of the 2015 Nikon Small World photomicrography contest (reprinted with permission of R.C.G.; image provided by Nikon).

Volume 12 Issue 11

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Editorial

  • The Indian parliament will soon discuss a bill regarding forensic DNA profiling, the terms of which will affect a vast population. It should not pass without substantial national debate and a provision for independent oversight.

    Editorial

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This Month

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Correspondence

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Research Highlights

  • Two computational tools extract strain-level information from reams of microbial sequence data.

    • Tal Nawy
    Research Highlights

  • Two strategies improve structured illumination microscopy for use in live-cell super-resolution imaging.

    • Rita Strack
    Research Highlights

  • A new probe allows for optical erasure of newly activated dendritic spines.

    • Brigitta B. Gundersen
    Research Highlights

  • An alternative to optogenetics, sonogenetics uses ultrasound to mechanically stimulate neurons.

    • Nina Vogt
    Research Highlights
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Methods in Brief

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Tools in Brief

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Research Highlights

  • A systematic analysis of protein-complex composition across a billion years of evolution reveals a spectrum of conservation.

    • Allison Doerr
    Research Highlights

  • Two computational tools find residues that determine the specificity of any kinase and the effects of mutations in these residues on the phenotype of cancer cells.

    • Nicole Rusk
    Research Highlights
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Technology Feature

  • It's been a long wait for nanopore sequencing technology. Over 1,000 labs are testing the first commercial device and publishing results. Researchers tell Nature Methods about their experiences putting these early instruments through their paces. And more technology is in the works.

    • Vivien Marx

    Collection:

    Technology Feature
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News & Views

  • Two approaches for robust, objective segmentation of single-molecule localization data promise better quantitative insights into protein clustering from super-resolution imaging methods.

    • David Baddeley
    News & Views
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Review Article

  • Applications of focused ion beams for biological ultrastructure and chemical imaging, with a particular emphasis on the coupling of this technology with scanning electron microscopy, are discussed in this Review.

    • Kedar Narayan
    • Sriram Subramaniam
    Review Article
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Analysis

  • This analysis compares 13 clustering methods on 24 data sets using the freely accessible ClustEval platform and presents guidelines for how to choose tools and set parameters for clustering biomedical data

    • Christian Wiwie
    • Jan Baumbach
    • Richard Röttger
    Analysis
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Resource

  • Z-Brain is an atlas of the larval zebrafish brain. It can be combined with pERK-based neural-activity measurements from freely behaving zebrafish to identify brain regions involved in generating behavior.

    • Owen Randlett
    • Caroline L Wee
    • Alexander F Schier
    Resource
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Brief Communication

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Article

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Corrigendum

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Advertising Feature: Application Note

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