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An oligodendrocyte stained for myelin basic protein (red) and DNA (blue) interacts with polystyrene nanofibers. Cover by Matt Hansen, based on an image provided by Seonok Lee and Jonah R. Chan.
Through a collaborative effort, engineers and neuroscientists have created a method, using electrospun nanofibers as surrogate neuronal axons, to piece together the complexities of myelination.
Many scholars claim there is a consensus on broad consent for biobanking. We analyzed the literature in PubMed and found no evidence for consensus. Public perception studies report mixed findings on consent, but many biobanks adopt broad consent. A belief in consensus may stem from knowledge of biobank consent practices.
In this perspective, the authors present the basic features of lens-free computational imaging tools and report performance comparisons with conventional microscopy methods. They also discuss the challenges that these computational on-chip microscopes face for their wide-scale biomedical application.
The mouse cancer model 'Multi-Hit' allows for the evaluation of oncogene cooperativities in tumor development based on stochastic Cre-recombination events. Cells with cooperating oncogenes are positively selected and give rise to tumors. The approach is used to study Ras downstream effector pathways in tumorigenesis.
pLink, software for data analysis of cross-linked proteins coupled with mass spectrometry, estimates false discovery rate and enables analysis of protein complexes without extensive purification.
A combination of protein correlation profiling–stable isotope labeling by amino acids in cell culture and size-exclusion chromatography allows stoichiometric analysis of changes in the human interactome in response to a growth factor.
Precise mass measurement on single mammalian cells is combined with imaging to monitor changes in cellular mass during the cell cycle over many generations.
Gene synthesis is currently limited by the need to use error-prone oligonucleotide building blocks. Dial-out PCR overcomes the sequence verification bottleneck by using unique sequence tags and massively parallel sequencing to identify and selectively retrieve error-free DNA molecules of interest from complex mixtures.
Primary rat oligodendocytes were cultured in the presence of electron-spun nanofibers of varying sizes as a model to study myelination processes in the mammalian central nervous system. The authors study the role of fiber diameter on the initiation of concentric wrapping by oligodendrocytes.
A method is presented to model cell proliferation from tracked automated time-lapse imaging of cell populations. The resulting fractional proliferation graphs permit visualization of dynamic changes in the dividing and nondividing subsets of the population.