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Correspondence

Nature Methods 6, 315–316 (1 May 2009) | doi:10.1038/nmeth.f.248

Massively parallel exon capture and library-free resequencing across 16 genomes

Emily H Turner , Choli Lee , Sarah B Ng , Deborah A Nickerson & Jay Shendure

To the Editor: The adoption of molecular inversion probes (MIPs) to massively parallel exon capture has been limited by representational and allelic bias. We modified this protocol, enabling simultaneous amplification and accurate shotgun sequencing of 50,000 exons.