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Brief Communication
Nature Methods 5, 311–313 (1 April 2008) | doi:10.1038/nmeth.1196
In vivo immunogold labeling confirms large-scale chromatin folding motifs
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Abstract
The difficulty in localizing specific cellular proteins by immuno-electron microscopy techniques limits applications of electron microscopy to cell biology. We found that in vivo immunogold labeling improves epitope accessibility, ultrastructural preservation and three-dimensional visualization, and allows correlated light and electron microscopy.
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