Nature Methods
- 5, 291 - 292 (2008)
doi:10.1038/nmeth0408-291
Disaccharide structure code for the easy representation of constituent oligosaccharides from glycosaminoglycansRoger Lawrence1, 4, Hong Lu2, 4, Robert D Rosenberg3, Jeffrey D Esko1 & Lijuan Zhang21
Roger Lawrence and Jeffrey D. Esko are in the Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California 92093, USA. jesko@ucsd.edu
2
Hong Lu and Lijuan Zhang are in the Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. lzhang@labmed.wustl.edu
3
Robert D. Rosenberg is in the Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. 4
Roger Lawrence and Hong Lu contributed equally to this work. Here we introduce a new shorthand nomenclature for designating the disaccharide subunit structure of all glycosaminoglycans as a way to compare compositions and describe linear sequences. Each disaccharide structural code (DSC) comprises four alphanumeric characters that reflect the actual substituents and isomeric characteristics of each component sugar. Larger structures can be represented easily by forming concatamers. The structural transparency of this new nomenclature eliminates the need for ambiguous acronyms or difficult numeric representations.
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