Nature Methods
- 5, 319 - 322 (2008)
Published online: 16 March 2008; | doi:10.1038/nmeth.1195
A quantitative analysis software tool for mass spectrometry–based proteomicsSung Kyu Park1, 2, John D Venable1, 2, Tao Xu1 & John R Yates III11
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, SR11, La Jolla, California 92014, USA. 2
These authors contributed equally to this work.
Correspondence should be addressed to John R Yates III jyates@scripps.edu We describe Census, a quantitative software tool compatible with many labeling strategies as well as with label-free analyses, single-stage mass spectrometry (MS1) and tandem mass spectrometry (MS/MS) scans, and high- and low-resolution mass spectrometry data. Census uses robust algorithms to address poor-quality measurements and improve quantitative efficiency, and it can support several input file formats. We tested Census with stable-isotope labeling analyses as well as label-free analyses.
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