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Structural genomics refers to the high-throughput effort of rapidly solving three-dimensional protein structures. Cover by Erin Boyle, using a selection of images of protein structures solved by various structural genomics consortia: the SGC, JCSG, NYSGXRC, RIKEN, OPPG, ISFI and AFMB. Commentary p129, Review p135, Perspective p147, Technology Feature p203
A single biomolecule carries information that becomes lost in an ensemble average. Methodological developments in imaging are now making it easier to access this hidden information in a live-cell context.
Nathan Blow visits the Joint Center for Structural Genomics for a glimpse inside one of the large-scale production centers for the Protein Structure Initiative.