Nature Methods
- 5, 129 - 132 (2008)
doi:10.1038/nmeth0208-129
Structural genomics: from genes to structures with valuable materials and many questions in betweenBrian G Fox1, Celia Goulding1, Michael G Malkowski1, Lance Stewart1 & Ashley Deacon11
Brian G. Fox is at the Center for Eukaryotic Structural Genomics, University of Wisconsin-Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA. 2
Celia Goulding is at the Integrated Center for Structure and Function Innovation, Molecular Biology Institute, 611 Young Drive East, University of California, Los Angeles, California 90095, USA. 3
Michael G. Malkowski is at the Center for High-Throughput Structural Biology, Hauptmann Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, New York 14203, USA. 4
Lance Stewart is at the Accelerated Technologies Center for Gene to 3D Structure, deCODE biostructures, 7869 NE Day Road West, Bainbridge Island, Washington 98110, USA. 5
Ashley Deacon is at the Joint Center for Structural Genomics, Stanford Synchrotron Radiation Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA.
Correspondence should be addressed to Brian G Fox bgfox@biochem.wisc.edu The Protein Structure Initiative (PSI), funded by the US National Institutes of Health (NIH), provides a framework for the development and systematic evaluation of methods to solve protein structures. Although the PSI and other structural genomics efforts around the world have led to the solution of many new protein structures as well as the development of new methods, methodological bottlenecks still exist and are being addressed in this 'production phase' of PSI.
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