Brief Communication abstract
Nature Methods 5, 935 - 938 (2008)
Published online: 5 October 2008 | doi:10.1038/nmeth.1256
High-speed, miniaturized fluorescence microscopy in freely moving mice
Benjamin A Flusberg1,3, Axel Nimmerjahn1,3, Eric D Cocker1,3, Eran A Mukamel1, Robert P J Barretto1, Tony H Ko1, Laurie D Burns1, Juergen C Jung1 & Mark J Schnitzer1,2
A central goal in biomedicine is to explain organismic behavior in terms of causal cellular processes. However, concurrent observation of mammalian behavior and underlying cellular dynamics has been a longstanding challenge. We describe a miniaturized (1.1 g mass) epifluorescence microscope for cellular-level brain imaging in freely moving mice, and its application to imaging microcirculation and neuronal Ca2+ dynamics.
- James H. Clark Center for Biomedical Engineering and Sciences, Stanford University, 318 Campus Drive, Stanford, California 94305, USA.
- Howard Hughes Medical Institute, Stanford University, 318 Campus Drive, Stanford, California 94305, USA.
- These authors contributed equally to this work.
Correspondence to: Mark J Schnitzer1,2 e-mail: mschnitz@stanford.edu
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