Nature Methods
- 4, 227 - 230 (2007)
Published online: 18 February 2007; | doi:10.1038/nmeth1012
The development of a bioengineered organ germ methodKazuhisa Nakao1, 2, Ritsuko Morita1, 2, Yasumitsu Saji1, 2, Kentaro Ishida1, 2, Yusuke Tomita1, 2, Miho Ogawa1, 2, Masahiro Saitoh3, Yasuhiro Tomooka1, 2 & Takashi Tsuji1, 21
Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, Japan. 2
Tissue Engineering Research Center, Tokyo University of Science, Noda, Chiba, 278-8510, Japan. 3
Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan.
Correspondence should be addressed to Takashi Tsuji t-tsuji@rs.noda.tus.ac.jp To bioengineer ectodermal organs such as teeth and whisker follicles, we developed a three-dimensional organ-germ culture method. The bioengineered tooth germ generated a structurally correct tooth, after both in vitro organ culture as well as transplantation under a tooth cavity in vivo, showing penetration of blood vessels and nerve fibers. Our method provides a substantial advance in the development of bioengineered organ replacement strategies and regenerative therapies.
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