Nature Methods
- 3, 179 - 181 (2006)
Published online: 17 February 2006; | doi:10.1038/nmeth855
Formation of human prostate tissue from embryonic stem cellsRenea A Taylor1, 2, 6, Prue A Cowin1, 6, Gerald R Cunha3, Martin Pera4, Alan O Trounson2, John Pedersen5 & Gail P Risbridger11
Centre for Urological Research, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia 3168. 2
Monash Immunology and Stem Cell Laboratories, STRIP 1, West Ring Road, Monash University, Clayton, Victoria, Australia, 3168. 3
Department of Anatomy, University of California, San Francisco, California 94143, USA. 4
Australian Stem Cell Centre, P.O. Box 8002, Monash University LPO, Clayton, Victoria, Australia, 3168. 5
TissuPath Laboratories, 165 Burwood Road, Hawthorn, Victoria, Australia, 3122. 6
These authors contributed equally to this work.
Correspondence should be addressed to Gail P Risbridger gail.risbridger@med.monash.edu.au Rodent models and immortalized or genetically modified cell lines are frequently used—but have limited utility—for studying human prostate development and maturation. Using rodent mesenchyme to establish reciprocal mesenchymal-epithelial cell interactions with human embryonic stem cells (hESCs), we generated human prostate tissue expressing prostate-specific antigen (PSA) within 8–12 weeks. This human prostate model shows species-conserved signalling mechanisms that could extend to integumental, gastrointestinal and genital tissues.
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