With the advent of microfluidics technology and the development of a user-friendly device, studying high-density colonies of microorganisms in controlled chemostatic conditions now becomes a reality.
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References
Groisman, A et al. Nat. Methods 2, 685–689 (2005).
Novick, A. & Szilard, L. Science 112, 715–716 (1950).
Novick, A. & Szilard, L. Proc. Natl. Acad. Sci. USA 36, 708–719 (1950).
Monod, J. Ann. Inst. Pasteur 79, 390–410 (1950).
Whitesides, G.M., Ostuni, E., Takayama, S., Jiang, X. & Ingber, D.E. Annu. Rev. Biomed. Eng. 3, 335–373 (2001).
Fu, A.Y., Chou, H.P., Spence, C., Arnold, F.H. & Quake, S.R. Anal. Chem. 74, 2451–2457 (2002).
Mao, H., Cremer, P.S. & Manson, M.D. A sensitive, versatile microfluidic assay for bacterial chemotaxis. Proc. Natl. Acad. Sci. USA 100, 5449–5454 (2003).
Balaban, N.Q., Merrin, J., Chait, R., Kowalik, L. & Leibler, S. Science 305, 1622–1625 (2004).
O'Toole, G., Kaplan, H.B. & Kolter, R. Annu. Rev. Microbiol. 54, 49–79 (2000).
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Balaban, N. Szilard's dream. Nat Methods 2, 648–649 (2005). https://doi.org/10.1038/nmeth0905-648
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DOI: https://doi.org/10.1038/nmeth0905-648
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