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Mime-seq achieves cell-type specific, methylation-based, microRNA tagging and sequencing to uncover cell-specific microRNomes in C. elegans and Drosophila.
An extensive evaluation of differential expression methods applied to single-cell expression data, using uniformly processed public data in the new conquer resource.
CRISPR-based single-cell pooled screens that use linked barcodes suffer from lost sensitivity due to lentiviral template switching. The barcode-free CROP-seq design circumvents this problem.
Labeling newly transcribed RNA with 5-ethynyluridine and adding biotin via click chemistry allows the analysis of the proteome bound to the various RNA species, including nascent RNA.