Staying awake and alert requires hypothalamic neurons that secrete the neurotransmitter hypocretin, also called orexin. A new study shows that feedback loops of hypocretin and glutamate neurons orchestrate the neuronal output that regulates arousal.
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References
von Economo, C. et al. in Der Schlaf (ed. Sarason, D.) 38–54 (Lehmann, München, Germany, 1929).
von Economo, C. Sleep as a problem of localization. J. Nerv. Ment. Dis. 71, 249–259 (1930).
Li, Y., Gao, X.-B., Sakurai, T. & van den Pol, A.N. Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron—a potential mechanism for orchestrating the hypothalamus arousal system. Neuron 36, 1169–1181 (2002).
Mignot, E., Taheri, S. & Nishino, S. Sleeping with the hypothalamus: emerging therapeutic target for sleep disorders. Nat. Neurosci. 5 (suppl.), 1071–1075 (2002).
Sutcliffe, J.G. & de Lecea, L . The hypocretins: setting the arousal threshold. Nat. Rev. Neurosci. 3, 339–349 (2002).
Mieda, M. & Yanagisawa, M. Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors. Curr. Opin. Neurobiol. 12, 339–345 (2002)
de Lecea, L., Sutcliffe, J.G. & Farbre, V. Hypocretin/orexins as integrators of physiological information. Neuropeptides 36, 85–95 (2002).
Shirasaka, T., Kunitake, T., Takasaki, M. & Kannan, H. Neuronal effects of orexins: relevant to sympathetic and cardiovascular effects. Regul. Peptides 104, 91–95 (2002).
Overeem, S., Mignot, E., van Diijk, J.G. & Lammers, G.J. Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives. J. Clin. Neurophysiol. 18, 78–105 (2001).
Taheri, S., Zeitzer, J.M. & Mignot, E. The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu. Rev. Neurosci. 25, 283–313 (2002).
Overeem, S., Scammell, T.E. & Lammers, G.J. Hypocretin/orexin and sleep: implications for the pathophysiology and diagnosis of narcolepsy. Curr. Opin. Neuro. 16, 739–745 (2002).
Draganski, B. et al. Hypothalamic grey matter changes in narcoleptic patients. Nature Med. 8, 1186–1188 (2002).
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Hajak, G., Geisler, P. Orchestrating sleep-wake functions in the brain. Nat Med 9, 170–171 (2003). https://doi.org/10.1038/nm0203-170
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DOI: https://doi.org/10.1038/nm0203-170
