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News and Views
Nature Medicine 9, 1458 - 1459 (2003)
doi:10.1038/nm1203-1458
JAKing up immunosuppression
Megan Sykes1
- Megan Sykes is at the Massachusetts General Hospital/Harvard Medical School, Transplantation Biology Research Center, Bone Marrow Transplantation Section, Boston, Massachusetts 02129, USA. e-mail: megan.sykes@tbrc.mgh.harvard.edu
Abstract
A new immunosuppressive agent makes its debut in primate models of kidney transplantation. The drug has the potential to join the ranks of immunosuppressants currently used in transplantation.
Successful organ and cell transplantation in humans is driven by combinations of drugs that suppress the immune system. The development of these drugs beyond the 'first generation', beginning with cyclosporine and followed by a variety of new agents, has expanded the spectrum of clinical transplantation.
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