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Nature Medicine 9, 1353 - 1354 (2003)
doi:10.1038/nm1103-1353
Breaking the pain barrier
Halina Machelska1, Paul A Heppenstall1 & Christoph Stein1
- Halina Machelska, Paul A. Heppenstall and Christoph Stein are at the Klinik für Anaesthesiologie, Charité-Universitätsmedizin, Campus Benjamin Franklin, Hindenburgdamm 30, D-12200 Berlin, Germany. e-mail: MACHELSKA@zop-admin.ukbf.fu-berlin.de
Abstract
Artemin reverses pain and neurochemical changes after nerve injury in an animal model. The molecule could potentially treat neuropathic pain, in which even the slightest touch can hurt (pages 1383–1389).
Some of the worst types of pain comes from no defined source, and can flare up in response to normally innocuous stimuli such as brushing of the skin or contact with clothing. Such pain, called neuropathic pain, is a major and often debilitating consequence of nerve damage.
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