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Nature Medicine 8, 213 - 214 (2002)
doi:10.1038/nm0302-213
Are somatic stem cells pluripotent or lineage-restricted?
Kevin A. D'Amour1 & Fred H. Gage1
- Laboratory of Genetics, Salk Institute La Jolla, California, USA
e-mail: gage@salk.edu
Abstract
The finding that fetal mouse neural stem cells do not differentiate into hematopoietic cells contradicts findings from earlier reports and adds to the controversy regarding the rigor of the experimental methods used to demonstrate the differentiation repertoire of stem cells. (pages 268–273)
Stem cells have become subject of intense research as models of developmental biology and for their promise of treating a variety of human diseases. Several reports suggest that fetal and adult neural stem cells (NSCs) are capable of differentiating into hematopoietic cells1, 2, 3.
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