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Nature Medicine 8, 1356 - 1358 (2002)
doi:10.1038/nm1202-1356
Immunotherapy tackles lupus
Gary M. Kammer1
- Section on Rheumatology and Clinical Immunology, Department of Internal Medicine and Department of Microbiology and Immunology, Wake Forest University Health Sciences Winston-Salem, North Carolina, USA e-mail: gmkammer@wfubmc.edu
Abstract
Dysregulation of T cells and B cells occurs in lupus and other autoimmune diseases. A monoclonal antibody therapy that seems to activate T cells restores some balance in a mouse model of lupus (pages 1405–1413).
The prototypical autoimmune disease is systemic lupus erythematosus, which mainly afflicts women during their childbearing years. Treatment of the disease with corticosteroids and cyclophosphamide has reduced mortality and significantly lengthened patients' life expectancies over the past three decades.
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