 | Figure 3
Nature Medicine
8, 1211 - 1217 (2002)
doi:10.1038/nm1102-1211
Atherogenesis in perspective: Hypercholesterolemia and inflammation as partners in crimeDaniel Steinberg | | | | Figure 3. Native LDL cannot induce foam-cell formation because uptake is slow and because its receptor downregulates.
Either acetyl LDL or oxLDL can induce foam-cell formation (cholesterol accumulation in macrophages) because uptake is rapid and the scavenger receptors do not downregulate in response to an increase in cellular cholesterol.
D. Maizels |
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