There is an Erratum (January 2003) associated with this Review.
Stabilization of atherosclerotic plaques: New mechanisms and clinical targets
Peter Libby
& Masanori Aikawa
Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Research points to pivotal roles for lipids in the development of atherosclerotic plaques. Lipid-lowering statins substantially reduce acute coronary events resulting from plaque development, but only modestly reduce arterial stenosis. This apparent paradox has shifted the goal of therapy towards plaque stabilization rather than enlargement of the lumen. More thorough understanding of the biology of atherosclerosis should enable us to manipulate plaque stability, and reduce further the acute complications of atherosclerosis.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated
but not by PPAR
activators
