The persistence of latently infected T cells is a major hurdle to eradication of HIV by antiviral therapy. It now seems that HIV latency can occur during normal T-cell differentiation in the thymus, and is regulated by the overall state of cellular gene transcription (pages 459–464).
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Koup, R. A new latent HIV reservoir. Nat Med 7, 404–405 (2001). https://doi.org/10.1038/86455
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DOI: https://doi.org/10.1038/86455
