One of the major challenges of the mad cow disease epidemic is the need for a good diagnostic test, to identify people and animals that have been infected with the infectious form of prion before symptoms appear. Differential display analysis may have revealed a good candidate marker (pages 361-364).
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Aguzzi, A. Blood simple prion diagnostics. Nat Med 7, 289–290 (2001). https://doi.org/10.1038/85423
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DOI: https://doi.org/10.1038/85423