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Volume 7 Issue 10, October 2001

The protein kinase Akt is a key downstream element of the insulin-signaling pathway, and is also known to control cell size in invertebrates. On page 1133 of this issue, Tuttle et al. show that specific overexpression of active Akt in mouse pancreatic ß cells increases cell size and islet mass and number. The cover image depicts insulin staining of cross-sections of pancreata from wild-type (upper) and transgenic (lower) mice. The transgenic pancreas shows a marked increase in number of islets (light blue). Magnification, x4.

Volume 7 Issue 10

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  • Behavioral studies demonstrate that the central mechanism involved in cocaine relapse is closely linked to the sites where marijuana has its effect, suggesting that cannabinoid receptor antagonists may be used as anti-craving agents. (pages 1151–1154)

    • Daniele Piomelli
    News & Views

  • Methicillin-resistant Staphylococcus aureus infections have become a major problem worldwide. The finding that two bacterial enzymes, one native and one acquired, cooperate to build cell walls in the presence of methicillin has drawn attention to an as yet unutilized target for new antibiotics.

    • Joachim-Volker Höltje
    News & Views

  • Several knockout mouse models of leanness and obesity resistance have been reported over the past several years and have advanced our understanding of the pathogenesis and treatment of obesity. A new lean mouse model has been generated by inactivating the gene for an inhibitor of mRNA translation. (pages 1128–1131)

    • Hubert C. Chen
    • Robert V. Farese Jr
    News & Views

  • Reflex epilepsies are caused by different sensory stimuli. The report of a gene that, when mutated, causes epileptic seizures in response to loud noises may provide important clues into the mechanisms of neuronal excitability.

    • Ram S. Puranam
    • James O. McNamara
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  • It has been known for over 20 years that vascular leakage in inflammation is dependent on neutrophils. The identification of the permeability-enhancing activity produced by neutrophils provides clues to the development of anti-inflammatory drugs with a new mechanism of action (pages 1123–1127).

    • Klaus Ley
    News & Views

  • The respiratory control system responds to hypoxia by increasing the rate of breathing. The finding that nitric-oxide–related molecules might control the ventilatory response to hypoxia suggests possible moleculartargets for the treatment of apnea.

    • José M. Mato
    • Matias A. Avila
    • Fernando J. Corrales
    News & Views

  • One neuronal characteristic of Parkinson disease is the presence of Lewy bodies–intracytoplasmic accumulations of protein. A new study draws a molecular link between the formation of these bodies, the ubiquitin protein degradation system, parkin and synphilin-1. (pages 1144–1150)

    • Aaron Ciechanover
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    • Alison Farrell
    • Charlotte Wang
    • Ushma Savla
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