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Nature Medicine 6, 351 - 354 (2000)
doi:10.1038/73219
In vivo magnetic resonance imaging of transgene expression
Ralph Weissleder1, Anna Moore1, Umar Mahmood1, Rajeev Bhorade1, Helene Benveniste2, E. Antonio Chiocca3 & James P. Basilion1,3
- Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, 5403, Charlestown, Massachusetts 02129, USA
- The Center for In vivo Microscopy, Duke University , Durham, North Carolina, USA
- Molecular Neurooncology Laboratory, Neurosurgery Service, Massachusetts General Hospital and Harvard Medical School, Boston , Massachusetts, USA
Correspondence to: Ralph Weissleder1 e-mail: weissleder@helix.mgh.harvard.edu
Real-time imaging of gene expression in vivo at high spatial resolutions has been a long-cherished goal in molecular research. If such techniques were available, both endogenous and exogenous (for example, gene therapy) expression could be studied in live animals and potentially in a clinical setting.
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