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| Editorial |  Top |
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Gene therapy and the germline p245
doi:10.1038/6429
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(48K)
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| Letters to Editor | Top |
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Calcineurin and human heart failure pp246 - 247
Hae W. Lim
& Jeffery D. Molkentin
doi:10.1038/6430
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(123K)
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Chinese genetics and ethics p247
Dorothty C. Wertz
doi:10.1038/6433
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(65K)
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Filing a complaint p247
Gideon Koren
doi:10.1038/6434
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(65K)
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| News | Top |
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Bruntland makes waves in her first six months at the WHO p249
Karen Birmingham
doi:10.1038/6435
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(95K)
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New global coalition for vaccine development p249
K. S. Jayaraman
doi:10.1038/6437
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(95K)
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Novo Nordisk invests in academic diabetes research p250
Phyllida Brown
doi:10.1038/6438
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(82K)
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No-consent trials raise concern pp250 - 251
Alan Dove
doi:10.1038/6442
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(108K)
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London college tailors staffing to increase RAE score p251
David Dickson
doi:10.1038/6443
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(79K)
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Funds bolster Canadian research p251
Karen Birmingham
doi:10.1038/6444
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(79K)
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South Africa plans home-grown HIV vaccine p252
Karen Birmingham
doi:10.1038/6445
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(84K)
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University opens first Institute for Coffee Studies p252
Karen Birmingham
doi:10.1038/6447
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(84K)
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Roslin Institute upset by human cloning suggestions p253
David Firn
doi:10.1038/6449
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(73K)
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Increased budget for German science ministry p253
Michael Simm
doi:10.1038/6451
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(73K)
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Wellcome Trust builds African research center p253
Stephen Cass
doi:10.1038/6452
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(65K)
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NCI defends research involving minority groups p254
Scott Gottlieb
doi:10.1038/6453
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(80K)
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Australian research papers make the grade p254
Rada Rouse
doi:10.1038/6455
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(80K)
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Correction to "NIH opens conflict-of-interest investigation"
p254
doi:10.1038/6456
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(80K)
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| Commentaries | Top |
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In utero gene therapy: The case against pp255 - 256
Paul R. Billings
doi:10.1038/6457
Abstract | Full text | PDF
(61K)
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In utero gene therapy: The case for pp256 - 257
Holm Schneider
& Charles Coutelle
doi:10.1038/6458
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(61K)
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| Book Reviews | Top |
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Blood p258
Reviewed by: Herbert A. Perkins
doi:10.1038/6460
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(71K)
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What remains to be discovered pp258 - 259
Reviewed by: Floyd E. Bloom
doi:10.1038/6462
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(87K)
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Born That Way pp259 - 260
Reviewed by: Dean Hamer
doi:10.1038/6464
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(95K)
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Heart Development p260
Reviewed by: Leslie A. Leinwand
doi:10.1038/6466
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(78K)
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| News and Views | Top |
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Brain stem cells change their identity pp261 - 262
Ronald D. McKay
doi:10.1038/6468
Abstract | Full text | PDF
(116K)
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Mesenchymal stem cells: No longer second class marrow citizens pp262 - 264
Stanton L. Gerson
doi:10.1038/6470
Abstract | Full text | PDF
(158K)
See also: Article by Horwitz et al. |
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New pieces to the prostate cancer puzzle pp264 - 265
Tapio Visakorpi
doi:10.1038/6472
Abstract | Full text | PDF
(109K)
See also: Article by Kadkol et al. | Article by Craft et al. |
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Etiologies of cardiomyopathy and heart failure pp266 - 267
Jeffrey A. Towbin, Karla R. Bowles
& Neil E. Bowles
doi:10.1038/6474
Abstract | Full text | PDF
(390K)
See also: Letters to Editor by Lim & Molkentin | Article by Badorff et al. | Article by Georgakopoulos et al. |
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Fas counter-attack−the best form of tumor defense? pp267 - 268
Joe O'Connell, Michael W. Bennett, Gerald C. O'Sullivan, J. Kevin Collins
& Fergus Shanahan
doi:10.1038/6477
Abstract | Full text | PDF
(310K)
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Implicating PARP and NAD+ depletion in type I diabetes
pp269 - 270
Maureen J. Charron
& Susan Bonner-Weir
doi:10.1038/6479
Abstract | Full text | PDF
(130K)
See also: Article by Burkart et al. |
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Shakespeare in love—with NMDA receptors? pp270 - 271
Stuart A. Lipton
& Nobuki Nakanishi
doi:10.1038/6481
Abstract | Full text | PDF
(111K)
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Malaria from Africa blows hot and cold pp272 - 273
Pierre Druilhe
& Jean Louis Pérignon
doi:10.1038/6483
Abstract | Full text | PDF
(100K)
See also: Article by Gupta et al. |
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NOS: Modulator, not mediator of cardiac performance pp273 - 274
Joshua M. Hare
& Jonathan S. Stamler
doi:10.1038/6486
Abstract | Full text | PDF
(127K)
See also: Article by Vandecasteele et al. |
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| Articles | Top |
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Modulation of oncogenic potential by alternative gene use in human prostate
cancer pp275 - 279
Shrihari S. Kadkol, Jonathan R. Brody, Jonathan Pevsner, Jining Bai
& Gary R. Pasternack
doi:10.1038/6488
Abstract | Full text | PDF
(198K)
See also: News and Views by Visakorpi | Article by Craft et al. |
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A mechanism for hormone-independent prostate cancer through modulation
of androgen receptor signaling by the HER-2/neu tyrosine kinase pp280 - 285
Noah Craft, Yuriy Shostak, Michael Carey
& Charles L. Sawyers
doi:10.1038/6495
Abstract | Full text | PDF
(202K)
See also: News and Views by Visakorpi | Article by Kadkol et al. |
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Reduced expression of neural cell adhesion molecule induces metastatic
dissemination of pancreatic  tumor cells pp286 - 291
Anne-Karina Perl, Ulf Dahl, Petra Wilgenbus, Harold Cremer, Henrik Semb
& Gerhard Christofori
doi:10.1038/6502
Abstract | Full text | PDF
(319K)
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Fas ligand (CD95 ligand) controls angiogenesis beneath the retina pp292 - 297
Henry J. Kaplan, Marc A. Leibole, Tongalp Tezel
& Thomas A. Ferguson
doi:10.1038/6509
Abstract | Full text | PDF
(170K)
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Neuroprotection by a caspase inhibitor in acute bacterial meningitis
pp298 - 302
J.S. Braun, R. Novak, K.-H. Herzog, S.M. Bodner, J.L. Cleveland
& E.I. Tuomanen
doi:10.1038/6514
Abstract | Full text | PDF
(419K)
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Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5 pp303 - 308
Cheryl K. Lapham, Marina B. Zaitseva, Shirley Lee, Tatiana Romanstseva
& Hana Golding
doi:10.1038/6523
Abstract | Full text | PDF
(213K)
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Transplantability and therapeutic effects of bone marrow-derived mesenchymal
cells in children with osteogenesis imperfecta pp309 - 313
Edwin M. Horwitz, Darwin J. Prockop, Lorraine A. Fitzpatrick, Winston W. K. Koo, Patricia L. Gordon, Michael Neel, Michael Sussman, Paul Orchard, Jeffrey C. Marx, Reed E. Pyeritz
& Malcolm K. Brenner
doi:10.1038/6529
Abstract | Full text | PDF
(221K)
See also: News and Views by Gerson |
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Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic
beta-cell destruction and diabetes development induced by streptozocin pp314 - 319
Volker Burkart, Zhao-Qi Wang, Jürgen Radons, Birgit Heller, Zdenko Herceg, Laura Stingl, Erwin F. Wagner
& Hubert Kolb
doi:10.1038/6535
Abstract | Full text | PDF
(224K)
See also: News and Views by Charron & Bonner-Weir |
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Enteroviral protease 2A cleaves dystrophin: Evidence of cytoskeletal
disruption in an acquired cardiomyopathy pp320 - 326
Cornel Badorff, Gil-Hwan Lee, Barry J. Lamphear, Maryann E. Martone, Kevin P. Campbell, Robert E. Rhoads
& Kirk U. Knowlton
doi:10.1038/6543
Abstract | Full text | PDF
(427K)
See also: Letters to Editor by Lim & Molkentin | News and Views by Towbin et al. | Article by Georgakopoulos et al. |
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The pathogenesis of familial hypertrophic cardiomyopathy: Early and evolving
effects from an  -cardiac myosin heavy chain missense mutation pp327 - 330
Dimitrios Georgakopoulos, Michael E. Christe, Michael Giewat, Christine M. Seidman, J.G. Seidman
& David A. Kass
doi:10.1038/6549
Abstract | Full text | PDF
(121K)
See also: Letters to Editor by Lim & Molkentin | News and Views by Towbin et al. | Article by Badorff et al. |
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Muscarinic and -adrenergic regulation of heart rate, force of contraction
and calcium current is preserved in mice lacking endothelial nitric oxide
synthase pp331 - 334
Grégoire Vandecasteele, Thomas Eschenhagen, Hasso Scholz, Birgitt Stein, Ignacio Verde
& Rodolphe Fischmeister
doi:10.1038/6553
Abstract | Full text | PDF
(164K)
See also: News and Views by Hare & Stamler |
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The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo pp335 - 339
Natalia V. Guevara, Han-Seob Kim, Ekaterina I. Antonova
& Lawrence Chan
doi:10.1038/6585
Abstract | Full text | PDF
(187K)
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Immunity to non-cerebral severe malaria is acquired after one or two
infections pp340 - 343
Sunetra Gupta, Robert W. Snow, Christl A. Donnelly, Kevin Marsh
& Chris Newbold
doi:10.1038/6560
Abstract | Full text | PDF
(124K)
See also: News and Views by Druilhe & Pérignon |
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CCR5- and CXCR4-tropic HIV-1 are equally cytopathic for their T-cell targets in human lymphoid tissue pp344 - 346
Jean-Charles Grivel
& Leonid B. Margolis
doi:10.1038/6565
Abstract | Full text | PDF
(533K)
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Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis pp347 - 350
Peter Klivenyi, Robert J. Ferrante, Russell T. Matthews, Mikhail B. Bogdanov, Autumn M. Klein, Ole A. Andreassen, Gerald Mueller, Marieke Wermer, Rima Kaddurah-Daouk
& M. Flint Beal
doi:10.1038/6568
Abstract | Full text | PDF
(181K)
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| New Technology | Top |
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Monitoring simultaneous subcellular events in vitro
by means of coherent multiprobe fluorescence pp351 - 355
Douglas R. Plymale, Jeffrey R. Haskins
& Felix A. de la Iglesia
doi:10.1038/6574
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(250K)
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Correction to "Gene expression profiles of laser-captured adjacent
neuronal subtypes" p355
doi:10.1038/6581
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(53K)
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On the market p356
doi:10.1038/6582
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(109K)
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