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Is calcium the 'cure' for dilated cardiomyopathy?

Nature Medicine volume 5, pages 1353–1354 (1999)Cite this article

Abstract

Different studies report different findings about the roles of calcium in myocyte function and in the development of dilated cardiomyopathy. But determining whether increasing intracellular calcium is helpful or harmful for heart failure patients will require further investigation.

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Figure 1: The cytoskeletal network and excitation contraction coupling in a working heart cell.

References

  1. Minamisawa, S. et al. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell 99, 313–322 (1999).

    Article  CAS  Google Scholar 

  2. Koss, K.L. & Kranias, E.G. Phospholamban: a prominent regulator of myocardial contractility. Circ. Res. 79, 1059–1063 (1996).

    Article  CAS  Google Scholar 

  3. Palmiter, K.A. & Solaro, R.J. Molecular mechanisms regulating the myofilament response to Ca2+: implications of mutations causal for familial hypertrophic cardiomyopathy. Basic Res. Cardiol. 92, 63–74 (1997).

    Article  CAS  Google Scholar 

  4. Chicurel, M.E., Singer, R.H., Meyer, C.J. & Ingber, D.E. Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions. Nature 392, 730–733 (1998).

    Article  CAS  Google Scholar 

  5. Rockman, H.A. et al. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc. Natl. Acad. Sci. USA 95, 7000–7005 (1998).

    Article  CAS  Google Scholar 

  6. Olson, E.N. & Molkentin, J.D. Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype? Circ. Res. 84, 623–632 (1999).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology and Biophysics (M/C 901) College of Medicine, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, 60612-7342, Illinois, USA

    R. John Solaro

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  1. R. John Solaro
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Solaro, R. Is calcium the 'cure' for dilated cardiomyopathy?. Nat Med 5, 1353–1354 (1999). https://doi.org/10.1038/70916

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