Nature Medicine
3, 1195 - 1196 (1997)
doi:10.1038/nm1197-1195
Healing hormonesJohn Rømer1, 2, Leif R. Lund1
& Keld Danø1
1The Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, DK-2100 Copenhagen, Denmark
2Novo Nordisk, NovoAllé 1, DK-2880 Bagsvoerd, Denmark Aging in women is accompanied by a reduced rate of skin wound healing, which is reversed by treatment with sex steroid hormones (pages 12091215). REFERENCES
- Martin, P. Wound healing Aiming for perfect skin regeneration. Science 276, 75−81 (1997). | Article | PubMed | ISI | ChemPort |
- Ashcroft, G.S. et al. Sex steroids accelerate cutaneous wound healing associated with an increase in TGF-
1 levels. Nature Med. 3, 1209−1215 (1997). | Article | PubMed | ISI | ChemPort |
- Schull, M.M. et al. Targeted disruption of the mouse transforming growth factor-
1 gene results in multi-focal inflammatory disease. Nature 359, 693−699 (1992). | Article | PubMed | ISI | ChemPort |
- Williams, A.O., Knapton, A.D., Geiser, A., Letterio, J.J. & Roberts, A.B. The liver in transforming growth factor beta 1 (TGF-beta 1) null mutant mice. Ultrastruct. Pathol. 20, 477−490 (1996). | PubMed | ISI | ChemPort |
- Guo, L. et al. Gene targeting of BPAG1: Abnormalities in mechanical strength and Cell migration in stratified epithelia and neurologic degeneration. Cell 81, 233−243 (1995). | Article | PubMed | ISI | ChemPort |
- Rømer, J. et al. Impaired wound healing in mice with a disrupted plasminogen gene. Nature Med. 2, 287−292 (1996). | Article | PubMed | ISI | ChemPort |
- Bugge, T.H. et al. Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency. Cell 87, 709−719 (1996). | Article | PubMed | ISI | ChemPort |
- Danø, K. et al. Plasminogen activators, tissue degradation and cancer. Adv. Cancer Res. 44, 139−266 (1985). | PubMed | ISI | ChemPort |
- Hewitt, R. & Danø, K., Stromal Cell expression of components of matrix degrading enzyme systems in human cancer. Enzyme Protein 49, 163−173 (1996). | PubMed | ISI | ChemPort |
- Rønnov-Jessen, L., Petersen, O.W. & Bissell, M.J. Cellular changes involved in conversion of normal to malignant breast; Importance of the stromal reaction. Physiol. Rev. 76, 69−125 (1996). | PubMed | ISI | ChemPort |
- Dvorak, H.F., Tumors : Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315, 1650−1659 (1986). | PubMed | ISI | ChemPort |
|