Extracellular DNA floating around in blood plasma provides an accessible template for detecting mutations associated with tumors. A new technique is able to quantify such mutated DNA and predict relapse in individuals with colorectal cancer. The technique complements other approaches, such as the analysis of tumor cells in the plasma (pages 985–990).
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Katie Vicari
References
Mandel, P. & Metais, P. C R Acad. Sci. Paris 142, 241–243 (1948).
Vasioukhin, V. et al. Br. J. Haematol. 86, 774–779 (1994).
Chen, X.Q. et al. Nat. Med. 2, 1033–1035 (1996).
Fleischhacker, M. & Schmidt, B. Biochim. Biophys. Acta 1775, 181–232 (2007).
Stroun, M. et al. Clin. Chim. Acta 313, 139–142 (2001).
Diehl, F. et al. Nat. Med. 14, 985–990 2008.
Diehl, F. et al. Gastroenterology 135, 489–498 (2008).
Maheswaran, S. et al. N. Engl. J. Med. 359, 366–377 (2008).
Lynch, T.J. et al. N. Engl. J. Med. 350, 2129–2139 (2004).
Lindforss, U. et al. Cancer 88, 2661–2667 (2000).
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Fleischhacker, M., Schmidt, B. Cell-free DNA resuscitated for tumor testing. Nat Med 14, 914–915 (2008). https://doi.org/10.1038/nm0908-914
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DOI: https://doi.org/10.1038/nm0908-914
