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Brief Communication
Nature Medicine 14, 819 - 821 (2008)
Published online: 27 July 2008 | doi:10.1038/nm.1850
Effective induction of high-titer antibodies by viral vector vaccines
Simon J Draper1, Anne C Moore1,5, Anna L Goodman1, Carole A Long2, Anthony A Holder3, Sarah C Gilbert1, Fergal Hill4 & Adrian V S Hill1
Abstract
Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus–poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.
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