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Bench to Bedside

Tempering antigen-presenting cells in multiple sclerosis

Nature Medicine volume 14, pages 614–615 (2008)Cite this article

A variety of immune cell types contribute to disease in individuals with multiple sclerosis, an autoimmune condition of the central nervous system. Thomas Prod'homme and Scott Zamvil comment on the 'Bench to Bedside' approach, examining how recent basic research implicates the antigen-presenting cell in this disease. In our 'Bedside to Bench' column, Hans Link explores how recent clinical trials may bolster a mechanistic role for the B cell.

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Figure 1: Signaling via IFN-β regulates differentiation of TH17 cells, a proinflammatory cell type that is thought to contribute to multiple sclerosis.

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Authors and Affiliations

  1. Thomas Prod'homme and Scott S. Zamvil are in the Department of Neurology and Program in Immunology, University of California San Francisco, 513 Parnassus Avenue S-268, San Francisco, California 94143-0114, USA. zamvil@ucsf.neuroimmunol.org,

    Thomas Prod'homme & Scott S Zamvil

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  1. Thomas Prod'homme
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  2. Scott S Zamvil
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Prod'homme, T., Zamvil, S. Tempering antigen-presenting cells in multiple sclerosis. Nat Med 14, 614–615 (2008). https://doi.org/10.1038/nm0608-614

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