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Brief Communication
Nature Medicine 14, 501 - 503 (2008)
Published online: 6 April 2008 | doi:10.1038/nm1746
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
Jia-Yi Li1, Elisabet Englund2, Janice L Holton3, Denis Soulet1, Peter Hagell4, Andrew J Lees3, Tammaryn Lashley3, Niall P Quinn5, Stig Rehncrona6, Anders Björklund7, Håkan Widner4, Tamas Revesz3,9, Olle Lindvall4,8,9 & Patrik Brundin1,9
Abstract
Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11–16 years) developed 
-synuclein–positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.
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