Brief Communication abstract

Nature Medicine 14, 507 - 509 (2008)
Published online: 6 April 2008 | doi:10.1038/nm1752

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

Ivar Mendez1,5, Angel Viñuela2,5, Arnar Astradsson2, Karim Mukhida1, Penelope Hallett2, Harold Robertson1, Travis Tierney2, Renn Holness1, Alain Dagher3, John Q Trojanowski4 & Ole Isacson2


Postmortem analysis of five subjects with Parkinson's disease 9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.

  1. Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.
  2. Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson's Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.
  3. McGill University and Montreal Neurological Institute, McConnell Brain Imaging Centre, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.
  4. Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging of the University of Pennsylvania, NINDS Udall Parkinson's Disease Research Center of Excellence, 3600 Spruce Street, Philadelphia, Pennsylvania 19104, USA.
  5. These authors contributed equally to this work.

Correspondence to: Ole Isacson2 e-mail:


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