News and Views
Focus on Reproductive Biology
- Focus issue:
- November 2008 Volume 14, No 11
Nature Medicine 14, 1187 - 1188 (2008)
doi:10.1038/nm1108-1187
Angiogenesis factors and preeclampsia
Ralf Dechend1 & Friedrich C Luft1
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Ralf Dechend and Friedrich C. Luft are in the Medical Faculty of the Charité, Franz-Volhard Clinic, HELIOS Klinikum-Berlin, Experimental and Clinical Research Center, Max-Delbrück Center for Molecular Medicine, Experimental and Clinical Research Building, Lindenberger Weg 80, 13125 Berlin, Germany.
e-mail: ralf.dechend@charite.de
Abstract
Two recent studies—one in humans by Levine et al. in 2004 and one in mice by Venkatesha et al. in 2006—have shown an important role for placental-derived soluble antiangiogenic factors as mediators of the pathologies associated with preeclampsia. These findings may have profound implications for the diagnosis, treatment and prevention of this devastating condition.
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