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News and Views
Nature Medicine 13, 280 - 282 (2007)
doi:10.1038/nm0307-280
Defining the 'survivasome' of Mycobacterium tuberculosis
Gyanu Lamichhane1 & William Bishai1
- The authors are at the Johns Hopkins School of Medicine, 1550 Orleans Street, Baltimore, Maryland, USA. e-mail: wbishai@jhmi.edu or e-mail: lamichhane@jhu.edu
Abstract
Identification of drug targets in M. tuberculosis is a challenge for bench science. High-throughput mutagenesis with transposons together with microarray-based genome and transcriptome profiling has begun to meet this challenge.
The worldwide mortality and morbidity due to tuberculosis remains excessive despite the availability of drugs that can stably cure it. Multiple factors underlie this paradox.
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