1. Marcel A. Behr is at McGill University Health Centre and McGill University, Division of Infectious Diseases and Medical Microbiology, A5-156, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.
2. David R. Sherman is at the Seattle Biomedical Research Institute and Pathology Department, University of Washington, Seattle, Washington 98109, USA. e-mail: marcel.behr@mcgill.ca

Abstract

The genomic region lost during the attenuation of BCG vaccine encodes a newly discovered secretion system conserved among gram-positive bacteria. A series of papers has now dissected the components of this system, revealing a unique Mycobacterium tuberculosis–specific signal for export of bacterial proteins into the host.

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