1. The authors are at the Johns Hopkins School of Medicine, 1550 Orleans Street, Baltimore, Maryland, USA. e-mail: wbishai@jhmi.edu or e-mail: lamichhane@jhu.edu

Abstract

Identification of drug targets in M. tuberculosis is a challenge for bench science. High-throughput mutagenesis with transposons together with microarray-based genome and transcriptome profiling has begun to meet this challenge.

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