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Nature Medicine 13, 1286 - 1287 (2007)
doi:10.1038/nm1107-1286
APC and colon cancer: two hits for one
Craig J Ceol1, David Pellman2,3 & Leonard I Zon1
- Stem Cell Program and Division of Hematology/Oncology, Children's Hospital, Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.
- Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Boston, Massachusetts 02115, USA.
- Department of Pediatric Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. e-mail: zon@enders.tch.harvard.edu
Abstract
Two studies suggest how mutations in the APC tumor suppressor gene can contribute to chromosomal aberrations in precancerous cells.
Many types of tumors, including those that arise in the intestinal tract, show substantial imbalances in allele copy number1, 2. A subset of these alterations is thought to have tumor-promoting consequences.
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