Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 13, 1282 - 1284 (2007)
doi:10.1038/nm1107-1282
Blocking HDACs boosts regulatory T cells
- Pavan Reddy is in the Department of Internal Medicine and Weiping Zou is in the Department of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA e-mail: reddypr@umich.edu
Abstract
Histone deacetylase inhibitors, which are in clinical use as anticancer agents, also affect the biology of regulatory T cells. These inhibitors may also hold promise as immunomodulatory drugs (pages 1299–1307).
Regulatory T cells (Treg cells) are key mediators of immune tolerance to both self and nonself antigens. Treg cells suppress the responses of conventional CD4+ T cells and other immune cells such as B cells, natural killer cells and dendritic cells in a variety of immune settings1.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Immunology Narcissistic helpersNature News and Views (26 Jul 2007)
Research highlightsNature Immunology News and Views (01 Feb 2006)
See all 3 matches for News And ViewsRESEARCH
Deacetylase inhibition promotes the generation and function of regulatory T cellsNature Medicine Article (01 Nov 2007)
