1. Stem Cell Program and Division of Hematology/Oncology, Children's Hospital, Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.
2. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Boston, Massachusetts 02115, USA.
3. Department of Pediatric Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. e-mail: zon@enders.tch.harvard.edu

Abstract

Two studies suggest how mutations in the APC tumor suppressor gene can contribute to chromosomal aberrations in precancerous cells.

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